H. pylori
Point-of-care rapid testing for h. pylori. OEM/ODM manufacturer.
Overview
Helicobacter pylori colonizes the gastric mucosa and is linked to gastritis, peptic ulcer and gastric cancer. Non-invasive testing supports test-and-treat strategies.
Clinical Context
Helicobacter pylori colonizes gastric mucosa, linked to gastritis, peptic ulcer and gastric cancer. Non-invasive testing supports test-and-treat.
Diagnostic Markers & Methods
Stool antigen (active infection) · serology (antibody, exposure) · urea breath test (reference non-invasive).
Antigen vs Antibody
Stool antigen detects active infection (suitable for test-of-cure); antibody serology detects exposure and cannot distinguish active from past.
Diagnostic Workflow
Symptomatic patient → stool antigen (active) or urea breath test → treat → test-of-cure after eradication.
Testing Window
Stool antigen detectable during active colonization; PPI/antibiotic washout before testing.
Interpretation
Stool antigen detects active infection and is suitable for post-treatment confirmation; serology cannot distinguish active from past infection.
False Negative / Positive Considerations
False negative: recent PPI or antibiotic use suppresses antigen. False positive: antibody serology stays positive after eradication.
Confirmatory Testing
Urea breath test or endoscopy with biopsy.
Testing Settings
Stool antigen suits clinics running test-and-treat; urea breath test is the reference non-invasive test.
Sources
Maastricht VI/Florence consensus (2022); ACG H. pylori guideline.
Progene's Take
Position: Prefer the stool antigen test over serology for H. pylori — it detects active infection and works for test-of-cure, which serology cannot.
- Antibody tests stay positive after treatment; stool antigen confirms eradication.
- Test-and-treat decisions need active-infection detection, not exposure history.
- PPI/antibiotic timing affects stool antigen — put that caveat on your datasheet.
This is the buyer-advisor view of the technical team — editorial guidance, not a substitute for product IFU or local regulatory requirements.
Frequently Asked Questions
Which H. pylori test is best for test-of-cure?
Stool antigen (or urea breath test) — they detect active infection and can confirm eradication. Antibody tests stay positive after treatment and are unsuitable for test-of-cure.
Do antibiotics or PPIs affect H. pylori stool antigen?
Yes — recent PPI or antibiotic use can suppress detection and cause false negatives; testing is usually done after a washout period.
Is H. pylori serology useful?
It indicates exposure but cannot distinguish active from past infection; use it mainly where stool testing or endoscopy is unavailable.
Related knowledge
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